Published 3/23/2020, last updated 5/21/2021

Medical Coding for COVID-19 Novel Coronavirus

COVID-19 ICD-10-CM Coding
COVID-19 ICD-10-PCS Coding
COVID-19 CPT® Coding
COVID-19 HCPCS Coding
COVID-19 DRG Coding
Optum360 COVID-19 Product Updates
We Are Here to Help
Other COVID-19 Resources

Optum360® is committed to ensuring that you have the information you need to effectively and efficiently address COVID-19 from a medical coding, billing and reimbursement perspective. We have compiled information from the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS), American Medical Association (AMA), and the Centers for Medicare and Medicaid Services (CMS), so you can easily access the most up-to-date medical code detail and effective dates in one convenient place.

COVID-19 ICD-10-CM Coding

There is one new ICD-10-CM code for COVID-19, effective April 1, 2020:

U07.1 COVID-19

The CDC posted the official ICD-10-CM Coding and Reporting Guidelines for COVID-19 for April 1, 2020-September 30, 2020.

The Centers for Disease Control and Prevention (CDC) issued a health alert on Thursday, May 14, 2020, outlining the case definition for multisystem inflammatory syndrome in children (MIS-C), which has been recently associated with COVID-19: COVID-19 Related Condition: Multisystem Inflammatory Syndrome in Children (MIS-C) (111 KB).

Six new ICD-10-CM codes were created for the capture of COVID-19 related encounters, effective January 1, 2021 through September 30, 2021.

J12.82

Pneumonia due to coronavirus disease 2019

M35.81

Multisystem inflammatory syndrome

M35.89

Other specified systemic involvement of connective tissue

Z11.52

Encounter for screening for COVID-19

Z20.822

Contact with and (suspected) exposure to COVID-19

Z86.16

Personal history of COVID-19

Summary of COVID-19 code changes as of 5.21.21 (256 KB).

COVID-19 ICD-10-PCS Coding

The Centers for Medicare and Medicaid Services (CMS) has added twelve new procedure codes to the International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS), effective August 1, 2020. These codes describe the introduction or infusion of therapeutics, including remdesivir and convalescent plasma, current treatments used to manage COVID-19 patients. These codes do not affect MS-DRG assignment.

XW013F5

Introduction of Other New Technology Therapeutic Substance into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 5

XW033E5

Introduction of Remdesivir Anti-infective into Peripheral Vein, Percutaneous Approach, New Technology Group 5

XW033F5

Introduction of Other New Technology Therapeutic Substance into Peripheral Vein, Percutaneous Approach, New Technology Group 5

XW033G5

Introduction of Sarilumab into Peripheral Vein, Percutaneous Approach, New Technology Group 5

XW033H5

Introduction of Tocilizumab into Peripheral Vein, Percutaneous Approach, New Technology Group 5

XW043E5

Introduction of Remdesivir Anti-infective into Central Vein, Percutaneous Approach, New Technology Group 5

XW043F5

Introduction of Other New Technology Therapeutic Substance into Central Vein, Percutaneous Approach, New Technology Group 5

XW043G5

Introduction of Sarilumab into Central Vein, Percutaneous Approach, New Technology Group 5

XW043H5

Introduction of Tocilizumab into Central Vein, Percutaneous Approach, New Technology Group 5

XW0DXF5

Introduction of Other New Technology Therapeutic Substance into Mouth and Pharynx, External Approach, New Technology Group 5

XW13325

Transfusion of Convalescent Plasma (Nonautologous) into Peripheral Vein, Percutaneous Approach, New Technology Group 5

XW14325

Transfusion of Convalescent Plasma (Nonautologous) into Central Vein, Percutaneous Approach, New Technology Group 5

The Centers for Medicare and Medicaid Services (CMS) added 21 new ICD-10-PCS procedure codes, effective January 1, 2021. These codes describe the introduction or infusion of therapeutics, including monoclonal antibodies and vaccines, for COVID-19 treatment. These codes do not affect MS-DRG assignment.

XW013F5

Introduction of other new technology monoclonal antibody into subcutaneous tissue, percutaneous approach, new technology group 6

XW013K6

Introduction of leronlimab monoclonal antibody into subcutaneous tissue, percutaneous approach, new technology group 6

XW013S6

Introduction of COVID-19 vaccine dose 1 into subcutaneous tissue, percutaneous approach, new technology group 6

XW013T6

Introduction of COVID-19 vaccine dose 2 into subcutaneous tissue, percutaneous approach, new technology group 6

XW013U6

Introduction of COVID-19 vaccine into subcutaneous tissue, percutaneous approach, new technology group 6

XW023S6

Introduction of COVID-19 vaccine dose 1 into muscle, percutaneous approach, new technology group 6

XW023T6

Introduction of COVID-19 vaccine dose 2 into muscle, percutaneous approach, new technology group 6

XW023U6

Introduction of COVID-19 vaccine into muscle, percutaneous approach, new technology group 6

XW033E6

Introduction of etesevimab monoclonal antibody into peripheral vein, percutaneous approach, new technology group 6

XW033F6

Introduction of bamlanivimab monoclonal antibody into peripheral vein, percutaneous approach, new technology group 6

XW033G6

Introduction of REGN-COV2 monoclonal antibody into peripheral vein, percutaneous approach, new technology group 6

XW033H6

Introduction of other new technology monoclonal antibody into peripheral vein, percutaneous approach, new technology group 6

XW033L6

Introduction of CD24Fc immunomodulator into peripheral vein, percutaneous approach, new technology group 6

XW043E6

Introduction of etesevimab monoclonal antibody into central vein, percutaneous approach, new technology group 6

XW043F6

Introduction of bamlanivimab monoclonal antibody into central vein, percutaneous approach, new technology group 6

XW043G6

Introduction of REGN-COV2 monoclonal antibody into central vein, percutaneous approach, new technology group 6

XW043H6

Introduction of other new technology monoclonal antibody into central vein, percutaneous approach, new technology group 6

XW043L6

Introduction of CD24Fc immunomodulator into central vein, percutaneous approach, new technology group 6

XW0DXM6

Introduction of baricitinib into mouth and pharynx, external approach, new technology group 6

XW0G7M6

Introduction of baricitinib into upper GI, via natural or artificial opening, new technology group 6

XW0H7M6

Introduction of baricitinib into lower GI, via natural or artificial opening, new technology group 6

Summary of COVID-19 code changes as of 5.21.21 (256 KB).

COVID-19 CPT® Coding

One new CPT® code was created for reporting new coronavirus 2 (SARS-CoV-2) COVID-19 testing, effective March 13, 2020.

87635

Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (New Coronavirus disease [COVID-19]), amplified probe technique)

Two new CPT® codes were created, one revised, for reporting COVID-19 antibody testing, effective April 10, 2020.

86318

Immunoassay for infectious agent antibody(ies), qualitative or semiquantitative, single step method (eg, reagent strip);

#86328

Immunoassay for infectious agent antibody(ies), qualitative or semiquantitative, single step method (eg, reagent strip); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19])

Code #86328 is a resequenced code that follows code 86318.

86769

Antibody; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19])

A new Proprietary Laboratory Analysis CPT® code was created for reporting coronavirus 2 (SARS-CoV-2) COVID-19 testing, effective May 20, 2020.

0202U

Infectious disease (bacterial or viral respiratory tract infection), pathogen-specific nucleic acid (DNA or RNA), 22 targets including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), qualitative RT-PCR, nasopharyngeal swab, each pathogen reported as detected or not detected

A new CPT code and two PLA CPT codes were created for reporting coronavirus 2 (SARS-CoV-2) COVID-19 testing, effective June 25, 2020.

87426

Infectious agent antigen detection by immunoassay technique, (eg, enzyme immunoassay [EIA], enzyme-linked immunosorbent assay [ELISA], immunochemiluminometric assay [IMCA]) qualitative or semiquantitative, multiple-step method; severe acute respiratory syndrome coronavirus (eg, SARS-CoV, SARS-CoV-2 [COVID-19])

0223U

0224U

Antibody, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), includes titer(s), when performed

Two new CPT codes and one PLA CPT code were created for reporting COVID-19 neutralizing antibody testing, and one additional PLA CPT code was created for reporting coronavirus 2 (SARS-CoV-2) COVID-19 testing, effective August 10, 2020.

#86408

Neutralizing antibody, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]); screen

#86409

Neutralizing antibody, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]); titer

Codes #86408 and #86409 are resequenced codes that follow code 86352.

0225U

Infectious disease (bacterial or viral respiratory tract infection) pathogen-specific DNA and RNA, 21 targets, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), amplified probe technique, including multiplex reverse transcription for RNA targets, each analyte reported as detected or not detected

0226U

Surrogate viral neutralization test (sVNT), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), ELISA, plasma, serum

Two new CPT codes were created, one for reporting COVID-19 antibody testing, and one for reporting additional supplies and clinical staff time required during a Public Health Emergency (PHE), effective September 8, 2020.

#86413

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) antibody, quantitative

Code #86413 is a resequenced code that follows code 86409.

99072

Additional supplies, materials, and clinical staff time over and above those usually included in an office visit or other nonfacility service(s), when performed during a Public Health Emergency, as defined by law, due to respiratory-transmitted infectious disease

Three new CPT codes were created for reporting coronavirus 2 (SARS-CoV-2) COVID-19 testing, two additional PLA CPT codes were created for reporting coronavirus 2 (SARS-CoV-2) COVID-19 testing, and one CPT code was revised, effective October 6, 2020.

87636

Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) and influenza virus types A and B, multiplex amplified probe technique

87637

Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), influenza virus types A and B, and respiratory syncytial virus, multiplex amplified probe technique

#87811

Infectious agent antigen detection by immunoassay with direct optical (ie, visual) observation; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19])

0240U

Infectious disease (viral respiratory tract infection), pathogen-specific RNA, 3 targets (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], influenza A, influenza B), upper respiratory specimen, each pathogen reported as detected or not detected

0241U

Infectious disease (viral respiratory tract infection), pathogen-specific RNA, 4 targets (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], influenza A, influenza B, respiratory syncytial virus [RSV]), upper respiratory specimen, each pathogen reported as detected or not detected

87426

Infectious agent antigen detection by immunoassay technique, (eg, enzyme immunoassay [EIA], enzyme-linked immunosorbent assay [ELISA], fluorescence immunoassay [FIA], immunochemiluminometric assay [IMCA]) qualitative or semiquantitative; severe acute respiratory syndrome coronavirus (eg, SARS-CoV, SARS-CoV-2 [COVID-19])

One new CPT code was created for reporting coronavirus 2 (SARS-CoV-2) COVID-19 testing, and six new codes for reporting COVID-19 vaccines, effective November 10, 2020.

87428

#0001A

Immunization administration by intramuscular injection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, preservative free, 30 mcg/0.3mL dosage, diluent reconstituted; first dose

#0002A

#0011A

#0012A

#91300

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, preservative free, 30 mcg/0.3mL dosage, diluent reconstituted, for intramuscular use

#91301

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, preservative free, 100 mcg/0.5mL dosage, for intramuscular use

Three new CPT codes were created for reporting COVID-19 vaccines, effective December 17, 2020.

#0021A

Immunization administration by intramuscular injection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, DNA, spike protein, chimpanzee adenovirus Oxford 1 (ChAdOx1) vector, preservative free, 5x10¹⁰ viral particles/0.5mL dosage; first dose

#0022A

#91302

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, DNA, spike protein, chimpanzee adenovirus Oxford 1 (ChAdOx1) vector, preservative free, 5x10¹⁰ viral particles/0.5mL dosage, for intramuscular use

Two new CPT codes were created for reporting COVID-19 vaccines, effective January 19, 2021.

#0031A

Immunization administration by intramuscular injection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, DNA, spike protein, adenovirus type 26 (Ad26) vector, preservative free, 5x1010 viral particles/0.5mL dosage, single dose

#91303

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, DNA, spike protein, adenovirus type 26 (Ad26) vector, preservative free, 5x1010 viral particles/0.5mL dosage, for intramuscular use

NOTE: A HCPCS code and CPT® code should not be reported together. Providers should contact third-party payer(s) for reporting either a CPT® or a HCPCS code, as well as for retroactive billing and reimbursement guidelines.

Summary of COVID-19 code changes as of 5.21.21 (256 KB).

COVID-19 HCPCS Coding

Two new HCPCS Level II codes were created for new coronavirus testing, effective April 1, 2020, for dates of service starting February 4, 2020.

U0001

CDC 2019 Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel For tests developed only by the CDC (reporting allows CDC testing laboratories to test new patients and track new cases).

U0002

2019-nCoV Coronavirus, SARS-CoV-2/2019-nCoV (COVID-19), any technique, multiple types or subtypes (includes all targets), non-CDC

For laboratories performing non-CDC testing.

Two new HCPCS Level II codes were created for coronavirus testing using high throughput technologies, effective April 14, 2020 (reportable for services provided on March 18, 2020 and forward).

U0003

Infectious agent detection by nucleic acid (DNA or RNA); Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), amplified probe technique, making use of high throughput technologies as described by CMS-2020-01-R.

U0004

2019-nCoV Coronavirus, SARS-CoV-2/2019-nCoV (COVID-19), any technique, multiple types or subtypes (includes all targets), non-CDC, making use of high throughput technologies as described by CMS-2020-01-R

Two new HCPCS Level II codes were created for specimen collection, effective March 1, 2020.

G2023

Specimen collection for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), any specimen source

G2024

Specimen collection for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) from an individual in a SNF or by a laboratory on behalf of a HHA, any specimen source

A new HCPCS Level II code was created for coronavirus specimen collection for hospital outpatient clinics effective March 1, 2020:

C9803

Hospital outpatient clinic visit specimen collection for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), any specimen source

Modifier CS was revised and may be appended to COVID-19 related testing services provided on or after March 18, 2020 to identify the cost-sharing waiver is applied and the Medicare patient should not be charged co-insurance or deductible.

Cost-sharing for specified COVID-19 testing-related services that result in an order for or administration of a COVID-19 test

Modifier CS was revised and may be appended to COVID-19 related testing services provided on or after July 1, 2020, to identify the cost-sharing waiver is applied and the Medicare patient should not be charged co-insurance or deductible, for services furnished via telehealth in Rural Health Clinics and Federally Qualified Health Centers.

Cost-sharing waived for specified COVID-19 testing-related services that result in an order for, or administration of, a COVID-19 test and/or used for cost-sharing waived preventive services furnished via telehealth in Rural Health Clinics and Federally Qualified Health Centers during the COVID-19 public health emergency

Two new HCPCS Level II codes were created for investigational monoclonal antibody therapy for specific patients who test positive for COVID-19.

M0239

Intravenous infusion, bamlanivimab-xxxx, includes infusion and post administration monitoring

Q0239

Injection, bamlanivimab-xxxx, 700 mg

Two new HCPCS Level II codes were created for investigational monoclonal antibody therapy for specific patients who test positive for COVID-19, effective November 21, 2020.

M0243

Intravenous infusion, casirivimab and imdevimab, includes infusion and post administration monitoring

Q0243

Injection, casirivimab and imdevimab, 2400 mg

Two HCPCS Level II codes were deleted, effective April 17, 2021 (originally newly effective on November 10, 2020).

M0239

Intravenous infusion, bamlanivimab-xxxx, includes infusion and post administration monitoring

Q0239

Injection, bamlanivimab-xxxx, 700 mg

Two new HCPCS Level II codes were created for investigational monoclonal antibody therapy for specific patients who test positive for COVID-19, effective May 6, 2021.

M0244

Intravenous infusion, casirivimab and imdevimab, includes infusion and post administration monitoring in the home or residence; this includes a beneficiary’s home that has been made provider-based to the hospital during the COVID-19 public health emergency

M0246

Intravenous infusion, bamlanivimab and etesevimab, includes infusion and post administration monitoring in the home or residence; this includes a beneficiary’s home that has been made provider-based to the hospital during the COVID-19 public health emergency

Summary of COVID-19 code changes as of 5.21.21 (256 KB).

COVID-19 DRG Coding

The CMS has released an update to the ICD-10 MS-DRG grouper software package to accommodate the new diagnosis code, U07.1 for COVID-19, effective with discharges on and after April 1, 2020.

The ICD-10 MS-DRG Grouper assigns each case into an MS-DRG based on the reported diagnosis and procedure codes and demographic information (age, sex, and discharge status).

The assignment of new ICD-10-CM diagnosis code U07.1 COVID-19 is as follows:

Diagnosis Code

Description

MDC

MS-DRG

U07.1

COVID-19

MCC

177,178,179

791,793

974,975,976

Summary of COVID-19 code changes as of 5.21.21 (256 KB).

Optum360 COVID-19 Product Updates

We recognize our coders rely on various resources and tools to access the most up-to-date medical codes. We are committed to ensuring you have all the information you need regarding COVID-19 codes, guidelines and effective dates.

Content updates pertaining to COVID-19 for your 2020 edition print books are now posted online:

ICD-10-CM (90 KB)| ICD-10-PCS | CPT® | HCPCS (63 KB) | DRG (140 KB)

Optum360 online coding tools (e.g. EncoderPro.com, RevenueCyclePro.com, etc.) published the necessary code and reference content updates on April 1, 2020. More information will be posted to the various online coding tool homepages – please sign in for details.

Optum360 data file/web service content is updated to include new COVID-19 codes. Please refer to the above-mentioned effective dates to comply with CDC, NCHS, AMA, and CMS guidelines. Log in to the data vault to access the newest content updates.

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Other COVID-19 Resources

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American Hospital Association

AHA COVID-19 Resource Center

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